Fundamental ignorance or illusion gives rise to earthly desires that in turn result in the accumulation of negative karma, trapping one in a cycle of migrating from one state of suffering to the next. “Eradicating karmic relations arising from ignorance” means to put an end to such transmigration at a root level and to eradicate and break free of the karmic relations that give rise to that cycle. Returning to the fundamental Mystic Law is the key.
This guidance is an abstract from 'The World of Nichiren Daishonin Writings' with universal value and application
By praying to the Gohonzon, which was inscribed based on the Ceremony in the Air, we become one with the eternal and universal life in the present. We can awaken a state of life in which we can survey the entire universe right from where we are. Through our daily practice of reciting the sutra and chanting Nam-myoho-renge-kyo, we can join the eternal Ceremony in the Air here and now. We can cause the treasure tower to shine within us and to shine within our daily activities and lives. That is the wonder of the Gohonzon. A magnificent cosmos of life opens to us, and reality becomes a world of value creation.
The treasure tower issues forth from deep within the earth and soars high into the sky above the saha world. This symbolizes the emergence from the eternal source or foundation of this world, the passage through the harsh realities of this realm of suffering, and a rising on toward the future and the fruition of lofty ideals.
Nichiren Daishonin states that he inscribed the Gohonzon as the “banner of propagation of the Lotus Sutra” (WND, 831). In other words, it is the object of devotion for kosen-rufu — that is, for accomplishing the wide propagation of the Mystic Law.
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